There's a nice article at the Institue of the Future of the Book blog about TeX and whether or not its a technological backwater.
I've been thinking about this kind of thing lately, feeling like I really need to get better at documenting my work. My typical approach is to learn lots of different things, none of them particularly well. So I know LaTeX passably well, a little bit of Word, a little bit of PowerPoint, and in order to keep a foot in the open source world, I've been trying out NeoOffice. For presentations, I also tried out the LaTeX Beamer class and created a PDF for a short talk a few weeks back.
I guess the general theme here is emphasizing (or at least not deemphasizing) the human element in the human-computer interaction/relationship.